<i>CBFA2T3::GLIS2</i>‐positive acute leukemia with RAM and mixed T/megakaryocytic phenotype

Herein, we present a rare case of acute myeloid leukemia (AML) with CBFA2T3-rearrangement and the expression megakaryocytic lymphoid markers, highlighting need for high suspicion index in differential diagnosis applying adequate workup to avoid misdiagnosing this entity. CBFA2T3::GLIS2-positive AML is primarily found infants non-down syndrome megakaryoblastic (non-DSAMKL). Flow cytometry immunophenotyping plays an important role recognizing unique immunophenotype bright CD56 dim/negative HLA-DR, CD38, CD45 termed RAM Still, T/megakaryocytic markers could be misdiagnosed as T-lymphoblastic leukemia/lymphoma, early T-cell precursor lymphoblastic NK leukemia, minimal differentiation, or myelodysplasia-related changes.